The thermotransient receptor potential (TRP) channels, such as transient receptor potential cation channel subfamily V member 1-4 (TRPV1-4) (23-27), transient receptor potential cation channel subfamily M member8 (TRPM8) (28, 29), and transient receptor potential cation channel subfamily A member 1 (TRPA1) (30), are the best-characterized molecular sensors for temperature in these systems. Among them, TRPV1, TRPV2, and TRPV4 have been shown to be expressed in adipocytes (31