There is a growing demand for fragranced products, but due to the poor aqueous solubility and
instability of fragrance molecules, their use is limited. Nowadays, fragrance encapsulation in
biocompatible nanocontainer material is emerging as a novel strategy to overcome the evaporation of
volatile molecules and to prolong the sensory characteristics of fragrance molecules and the longevity of
perfumes. The objective of this study was to develop an innovative sustained release system of perfume,
by entrapping fragrance molecules in a polymeric nanocarrier; the impact of this strategy on the human
axillary microbiome was further assessed. Stabilised poly-L-lactic acid nanocapsules (PLA-NCs) with a
diameter of approximately 115 nm were prepared through nanoprecipitation. Size and morphology of
the capsules were evaluated using Transmission Electron Microscopy (TEM) and Dynamic Light
Scattering (DLS). Two model hydrophobic compounds, chlorobenzene and fluorescein, representing
two different types of functionalised molecules, were encapsulated in PLA-NCs with an efficiency rate of
50%. Different release behaviours were seen, dependent on hydrophobicity. For hydrophobic
compounds, a steady release was observed over 48 hours. The polymeric nanocarriers did not impact the
human axillary microbiome. Because of the slow and sustained release of fragrances, encapsulation of
molecules in biocompatible NCs can represent a revolutionary contribution to the future of toiletries,
body deodorant products, and in washing and cleaning sectors.