In the current found that complication in the hospital the prevalence and the evolution of microbial resistance to antibiotics and disinfectants in the hospital. it is clear and sustainable to address contaminated surfaces in hospital are of great interest. Besides measures that deal with person-to-person transmission of pathogens contaminated environmental surfaces provide an important potential source for transmission of many healthcare-associated pathogens due to their persistence on such inanimate surfaces .This study exploited the hypothesis proposed by Falagas & Makris to use non-pathogenic microorganisms,namely probiotics, as part of daily cleaning products to lower. the incidence of HAI-related microorganisms
in healtcare facilities.