Weperformedadietaryprimarypilot intervention study to determine whether delaying the introduction of gluten to the dietmaybebeneficialinreducingtherisk oftype1diabetes–associatedisletautoimmunity in children with a predetermined genetic risk of islet autoimmunity, which was ~15% of children (11). We specifically assessed the feasibility of such an intervention, the safety with respect to growth, the development of glutendriven celiac disease, and, as a pilot efficacy measure, the cumulative frequency of islet autoimmunity by age 3 years.