Interestingly, analysis of the distribution of genes by pathways defined by the KEGG revealed clustering of the differentially expressed genes in cell junction pathways. Cell junctions include ‘focal adhesions’, ‘tight junctions’, ‘gap junctions’, ‘adherens junctions’, ‘desmosomes’, and ‘hemidesmosomes’, and each one plays a specific role in adhesion, communication, and transduction of mechanical force.