As mentioned earlier, fermentation is a useful biotechnological strategy for legumes that produces beneficial bioactive
phytochemicals. However, the influences of fermentation on the antioxidant activity and phenolic compounds of soy whey
have received little attention. Therefore, the aim of this study was to investigate soy whey fermented with Lactobacillus
plantarum B1–6 as a starter culture in order to improve the content of antioxidant compounds, antioxidant capacity, as well as DNA damage protecting ability. High performance liquid chromatography (HPLC) analysis was carried out to determine the content of each major isoflavone of soy whey before and after fermentation. To the best of our knowledge, this is the first report on the greater protection against oxidative DNA damage of fermented soy whey. The work investigated to obtain fermented soy whey with added-value and to develop it into a potential functional beverage. Meanwhile, the work may also be beneficial toward waste treatment and its consequences.