In common with most species, rodents as they age become progressively more
susceptible to naturally occurring diseases that can modify clinical pathology results and
thus obscure meaningful interpretation. Quantitative clinical chemistry and urinalysis
should, therefore, be generally avoided in rodents during their second year of life.
Clinical pathology evaluation in these animals, generally undertaken towards the end of a
carcinogenicity study, should be confined to a haematological evaluation of blood smears
taken from decedents and at study termination to aid in the interpretation and
differentiation of haemopoietic neoplasia. For both rodents and non-rodents, clinical
pathology testing should be performed on the same animals as examined for
morphological pathology findings and it is also recommended that blood samples from
recovery or withdrawal satellite groups should be analysed at study termination
In common with most species, rodents as they age become progressively moresusceptible to naturally occurring diseases that can modify clinical pathology results andthus obscure meaningful interpretation. Quantitative clinical chemistry and urinalysisshould, therefore, be generally avoided in rodents during their second year of life.Clinical pathology evaluation in these animals, generally undertaken towards the end of acarcinogenicity study, should be confined to a haematological evaluation of blood smearstaken from decedents and at study termination to aid in the interpretation anddifferentiation of haemopoietic neoplasia. For both rodents and non-rodents, clinicalpathology testing should be performed on the same animals as examined formorphological pathology findings and it is also recommended that blood samples fromrecovery or withdrawal satellite groups should be analysed at study termination
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