Two of Vázquez's four losses have come to Saul Alvarez, who he went the distance with Vázquez on two different occasions in Welterweight bouts.[3][4] His other loss was to Timothy Bradley when he was 20 years old at Light Welterweight, Bradley would go on to say "I knew the fight was going to be tough, he's Mexican, I give him a lot of credit he's a good fighter."[5]
On July 17, 2009 Vázquez became Infamous to boxing fans when he won a 10 round split decision over the undefeated and much heralded Breidis Prescott.[6][7] Prescott was the first fighter to beat England's Amir Khan.[8]