. Potent Melatonin: Melatonin was discovered about 50 years ago and it has very potent antioxidant properties which comprises of over 200% more power than glutathione, vitamin C and E and it is effective against damage caused by free-radicals. Melatonin combats cancer and cardiovascular disease caused by free-radicals. The brain naturally produces some amounts of melatonin, however if you are over 55 years old or you are diabetic your melatonin levels would need to be augmented with supplements.