Uric acid is the end product of purine metabolism in humans. High levels are causative in gout and urolithiasis.
Hyperuricaemia has also been implicated in the pathophysiology of hypertension, chronic kidney disease (CKD),
congestive heart failure (CHF), the metabolic syndrome, type 2 diabetes mellitus (T2DM), and atherosclerosis, with
or without cardiovascular events. This article briefly reviews uric acid metabolism and summarizes the current
literature on hyperuricaemia in cardiovascular disease and related co-morbidities, and emerging treatment options.