One gram of chitosan was dissolved in 100 mL 1.5% (V/V) acetic acid under occasional stirring for 48 h. The resulting viscous chitosan solution was filtered through nylon gauze to remove debris and suspended particles. To improve patch performance and release characteristics, a water‐soluble hydrophilic additive, polyvinylpyrrolidone (PVP K‐30), was added. The drug (Curcumin 10 mg with Asiaticoside cum madecassoside 10:10 mg) and PVP K‐30 were added into the chitosan solution under constant stirring. Propylene glycol (5%, V/V) was added into the solution as plasticizer under constant stirring. This viscous solution was left overnight at room temperature to ensure a clear, bubble‐free solution. The solution was poured into a glass Petri dish (6 cm diameter) , (figure 2) and allowed to dry at ambient temperature till a flexible film was formed. Dried films were carefully removed, checked for any imperfections or air bubbles and cut into patches of 16 mm in diameter, containing 9 mg drug per patch. The patches were packed in aluminum foil and stored in an airtight glass container to maintain the integrity and elasticity of the patches.