tA mass propagation protocol for Dendrobium ‘Zahra FR 62’, the result of hybridization between Dendro-bium ‘Sonia Deep Pink’ × Dendrobium 1265, was successfully established. Half-strength Murashige andSkoog (MS) medium containing 1 mg/L thidiazuron (TDZ) and 0.5 mg/L N6-benzyladenine (BA) resultedin high protoccorm-like body (PLB) formation and initial proliferation of Dendrobium using shoots asthe donor explant via repeated subcultures. High proliferation and optimal growth of PLBs was possibleby culturing PLBs in a 3-L bioreactor with 10 vessel volumes per minute (vvm) (CS-9) containing half-strength MS medium with 0.05 mg/L BA (M-2). A total of 807.7 PLBs formed with an average of 247.5new PLBs per subculture.