This may not be a true bioavailability
as is observed by the potential discrepancy
in the clearances. Clearance rates were similar among
the groups but slightly less (0.10 μg × mL−1 × h−1)
than those previously reported between 0.16 and 0.22
μg × mL−1 × h−1 (Kniffen et al., 1989; Nielsen and
Gyrd-Hansen, 1996), which adds credence to the apparent
bioavailability not being a true bioavailability.
Based on this Foral value, volumes of distribution at
steady state (Vdss) also were calculated but cannot be
directly compared with previous PK studies values of
Vdarea or Vdinitial because they may not be equivalent
(Williams, 1999).