The microscopic photograph from pancreatic hematoxylin eosin staining demonstrated a destruction of the pancreatic islet cells, such as shrink and irregular shape, in diabetic control rats. The islet cells of the diabetic rats treated with D. reticulata extract provides the evidence of less degeneration. An increase in the levels of hepatic enzymes, such as AST, ALT, glutamate-oxaloacetate transaminase (GOT) and glutamate-pyruvate transferase (GPT), has been established in diabetic rats induced by toxic chemicals, including alloxan and streptozotocin [6, 9]. In this study, alloxan-induced i of AST and ALT were decreased in rats administrated with D. reticulata extract compared to diabetic control group. In addition to pancreas, the result suggested that the extract also exerted hepatoprotective activity