The crude extract of Carissa carandas possesses laxative and
antidiarrheal properties mediated through a combination of gut
stimulant and inhibitory activities. The gut stimulant potential of
Carissa carandas was found mediated through combination of
muscarinic and histaminergic receptors activation, while its gut
inhibitory activity was observed mediated through Caþ þ antagonistic
pathway. Thus, this study provides a rationale for the
medicinal use of Carissa carandas in constipation and diarrhea.