Hydrolysis of carbohydrate polymers represents one of themost important biotechnologies in the 21st century given theincreasing demands for cellulose biomass-derived fuels. The keyenzymes in this process (cellulases and hemicellulases) are pro-duced by a wide variety of microorganisms [1] and their importancehas prompted the development of various methods for highthroughput screening and selection of microbial producers. Com-mon screening techniques involve plate assays, where the target polymer substrate or a derivative has been incorporated intoa basal growth medium. Bacteria with extracellular cellulolyticactivity are typically detected on agar media plate containingcarboxymethylcellulose (CMC) or xylan as substrates. These sub-strates are polysaccharide organic compounds consisting of a linearchain of (1-4) linked d-glucose units and xylopyranose residues,respectively. Substrate hydrolysis can be revealed by clearing zonesformed around the growing colonies after dye staining by Gram’siodine [2–8] or Congo red