We looked at direct comparisons of ICS versus placebo separately from comparisons of ICS/LABA versus LABA for all outcomes,
and we combined these with subgroups when no important heterogeneity was noted. After assessing for transitivity, we conducted
an indirect comparison to compare budesonide versus fluticasone monotherapy, but we could not do the same for the combination
therapies because of systematic differences between the budesonide and fluticasone combination data sets.