Certain forms of chemotherapy plus supportive care improve both survival and quality of life in patients with advanced gastrointestinal cancers compared to supportive care alone. Gastrointestinal cancer is the second most common form of cancer and is associated with a high mortality. There is some consistent evidence that patients with advanced gastrointestinal cancer benefit in both survival and quality of life by a combination of chemotherapy plus supportive care compared to receiving supportive care alone.