Histological changes after SP exposure
Edema and vasodilation
When applied directly to the culture medium, SP induced
vasodilatation in the superficial dermis: the global % of capillary dilatation was 77.7 ± 17.8% compared to control with
69 ± 8.9% (p = 0.05). The application of the bacterial
extract during SP stimulation tends to decrease the % of vessel dilatation, 69.06 ± 20.1% compared to the stimulation
with SP alone (p = 0.054).
From measurements of mean capillary surface, we
found that SP induced statistically significant vasodilation
compared to control [144.4 ± 71.2 lm2 with SP vs
107.66 ± 71.63 lm2 without (p = 0.02)].