Recently Toran-allerand in a comprehensive review article discussed the very existence of a variety of non-ERα / non-ERβ nuclear, cytoplasmic and plasma membrane ERs in the brain, including G protein coupled receptors, a novel developmentally regulated membrane associated ER (ER-X) and other variants of ERs. These ERs may differ immunologically, structurally and functionally from ERα and ERβ [26].