This review summarizes usage of genome-editing technologies for metagenomic studies; these studies are used
to retrieve and modify valuable microorganisms for production, particularly in marine metagenomics. Organisms
may be cultivable or uncultivable. Metagenomics is providing especially valuable information for uncultivable
samples. The novel genes, pathways and genomes can be deducted. Therefore, metagenomics, particularly
genome engineering and system biology, allows for the enhancement of biological and chemical producers
and the creation of novel bioresources. With natural resources rapidly depleting, genomics may be an effective
way to efficiently produce quantities of known and novel foods, livestock feed, fuels, pharmaceuticals and fine
or bulk chemicals