Change Strategies
To assess the potential impact of theoretical interventions designed
to reduce delay on the current thrombolysis pathway, a series of
change strategies were derived from the literature (Table 1).21-26
Some of these strategies, such as improving recording of onset time
or removing ineligibility of older patients for thrombolysis could be
implemented straight away if found to be cost-effective. Others, such
as the use of new imaging techniques to define onset time in wakeup
stroke remain theoretical and require a greater evidence base to
prove effectiveness before implementation. However, it is still useful
to know whether such strategies would be cost-effective in clinical
practice, therefore justifying whether further research is worthwhile.
Change strategies were implemented under 2 assumptions: (1) perfect
implementation (affecting 100% of patients) and (2) best achievable
implementation, based on previous studies, which have demonstrated
the effectiveness of a given intervention (Table 1).
Change StrategiesTo assess the potential impact of theoretical interventions designedto reduce delay on the current thrombolysis pathway, a series ofchange strategies were derived from the literature (Table 1).21-26Some of these strategies, such as improving recording of onset timeor removing ineligibility of older patients for thrombolysis could beimplemented straight away if found to be cost-effective. Others, suchas the use of new imaging techniques to define onset time in wakeupstroke remain theoretical and require a greater evidence base toprove effectiveness before implementation. However, it is still usefulto know whether such strategies would be cost-effective in clinicalpractice, therefore justifying whether further research is worthwhile.Change strategies were implemented under 2 assumptions: (1) perfectimplementation (affecting 100% of patients) and (2) best achievableimplementation, based on previous studies, which have demonstratedthe effectiveness of a given intervention (Table 1).
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