CONCLUSIONS
Our study suggests that an alternate TDM-guided strategy for diagnosing PA in patients with apparent TRH is associated with lower cost by selectively targeting the subset of patients at the highest risk for PA for further testing with minimal impact on efficiency in detecting PA. Future prospective studies are needed to confirm the difference in the prevalence of PA between adherent vs nonadherent patients with TRH and compare the effectiveness of a TDM-guided approach in terms of BP reduction and hypertensive target organ complications.