Multiple Myeloma(MM)
• primary malignant neoplasm of plasma cells arising in
bone marrow (immature B lymphocyte)
• enters bloodstream and travels to lymphoid tissue; activated by an antigen-presenting cell(APC) and exposed to an antigen, becoming a centroblast
• initially affects bones and bone marrow of vertebrae, ribs, skull, pelvis, and femur
• Progression>>damage kidney > leads to recurrent infections, and affects nervous system