Anaemia in patient of terminal chronic kidney disease have importance cause from body make decrease (Erythropoietin:EPO) hormones in anabolism red blood cell . The normal concentration of blood have range control 33-36 % , If more than or less than normal concentration of blood will be incurrent disease So that it have inject Erythropoietin hormones for creation activate red blood cell at bone-marrow in order to protect Anaemia. For this work have develop inject Erythropoietin to form Hydrogel Microneedle can transdermal delivery of Erythropoietin without needle tip materials to the skin. For the hydrogels are commonly used in drug delivery field further have properties dissolving and degradable microneedles , we used PVA formed of biocompatible to make Hydrogel Microneedle and study control release of Erythropoietin in Hydrogel Microneedle