All 4 groups displayed decreases in blood pressure, fasting plasma glucose, postprandial plasma glucose, lipid profile, and hs-CRP; but only the resistance and combined groups demonstrated increased IRS-1 expression after training. The improvement in these parameters in the training and no training groups may reflect differences in uncontrolled variables, medication adherence, or the reduction of antidiabetic drugs in the training groups (resistance and combined); but the molecular findings confirmed the beneficial effects of exercise training