• Preterm labor with a premature baby.
• Very low birth weight babies that are less than 3 pounds, especially with triplets or mores.
• Premature rupture of the membranes.
• Twin to twin blood transfusion with one baby anemic and the other baby with too much blood in its system. There may also be heart failure.
• With triplets or more, one of the babies is at high risk for cerebral palsy or other neurologic problem.
• There is a higher incidence of fetal death.