Ethambutol is an oral chemotherapeutic agent
which is specifically effective against actively
growing microorganisms of the genus Mycobacterium,
including M. tuberculosis (PDR,1989). Ethambutol is
bacteriostatic and appears to inhibit the synthesis of
one or more metabolites, thus causing impairment of
cell metabolism, arrest of multiplication, and cell
death. No cross resistance with other available
antimycobacterial agents has been demonstrated.
Ethambutol has been shown to be effective against
strains of mycobacterium tuberculosis but does not seem
to be active against fungi, viruses, or other bacteria.
Ethambutol is also active against some atypical
mycobacteria including M. kansasii. Primary resistance
to ethambutol is uncommon in developed countries but
resistant strains of M. tuberculosis are readily
produced if the drug is used alone.
Ethambutol is an oral chemotherapeutic agent which is specifically effective against actively growing microorganisms of the genus Mycobacterium, including M. tuberculosis (PDR,1989). Ethambutol is bacteriostatic and appears to inhibit the synthesis of one or more metabolites, thus causing impairment of cell metabolism, arrest of multiplication, and cell death. No cross resistance with other available antimycobacterial agents has been demonstrated. Ethambutol has been shown to be effective against strains of mycobacterium tuberculosis but does not seem to be active against fungi, viruses, or other bacteria. Ethambutol is also active against some atypical mycobacteria including M. kansasii. Primary resistance to ethambutol is uncommon in developed countries but resistant strains of M. tuberculosis are readily produced if the drug is used alone.
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