Echocardiography. Two-dimensional Doppler echocardiography will be performed with standard techniques (Philips iE33/ViCare, Denmark), corresponding to national and international guidelines for a full echocardiography [68] including valve function, with focus on diastolic function (E/A ratio), left atrial size (mm), and left atrial volume (mL). Data will be analysed blinded to randomization group and time of echocardiography using EchoPac/Excelera.