Standardized Incidence Ratios (SIRs) for Selected Cancers among Patients Followed for One Year after Hospitalization for Primary Deep Venous Thrombosis or Pulmonary Embolism. shows the risks of various types of cancer in the two cohorts during the first year of follow-up. The overall risk of the subsequent diagnosis of the neoplasms listed in Table 1 was 2.2 for the group with deep venous thrombosis and 2.3 for the group with pulmonary embolism. For both cohorts there were strong associations with certain types of cancer — in particular, cancer of the pancreas, ovary, liver (primary hepatic cancer), and brain. We found no association in either cohort with a few types — namely, cancer of the breast, urinary bladder, and rectum, and malignant melanoma. Of the 560 cases of cancer that were diagnosed during the first year of follow-up, we had no information about the extent of the disease at the time of diagnosis in 95 cases (17 percent). Of the remaining 465 cases, 184 (40 percent) had distant metastases, 115 (25 percent) had regional spread of the disease, and 166 (36 percent) had no spread.
During the period of follow-up beyond one year, the overall occurrence of cancer was slightly though significantly increased in both cohorts