Dietary probiotic bacteria simultaneously stimulate the anti-inflammatory regulatory arm of the immune system and the hypothalamus-pituitary-adrenal (HPA) axis to secrete cytokines and hormones that interrupt a destructive chronic pro-inflammatory cycle, culminating in superb host physique and reproductive health. In practical terms, probiotic-induced phenotypes not only imbue good health to the host, but are also inherently charismatic and attractive to others as they overtly signal leadership and reproductive potential. Under favorable conditions, the probiotic bacteria also benefit, as they are then passed from mother to offspring during birth and nursing, imparting evolutionary success to both species. Humans have cultivated and consumed similar food-grade probiotic organisms in fermented beverages and active yogurts for thousands of years, supporting a low-risk, high-impact population-based microbe-endocrine-immune approach for overall good health.