Passive transfer of serum collected from survivors of Junin virus or
Lassa virus, equine IgG product from horses hypervaccinated with Ebola virus, a “cocktail”
of humanized-mouse antibodies (ZMapp), recombinant inhibitor of factor VIIa/tissue factor,
activated protein C, RNA-polymerase inhibitors and small interfering RNA nano particles
are among the therapies in development. Preclinical evaluation is also underway for various
vaccine candidates. One is a chimpanzee adenovirus vector vaccine; other vaccines involve
replication-defective adenovirus serotype 5 and recombinant vesicular stomatitis virus