Logistics management in transport efficiency. It will help reduce costs and profits. Also help customers satisfaction in delivering goods quickly. Create a good image for company. The objective of this research is to reduce the cost of transportation system by using case Milk Run Company Limited ABC studied data transport goods to the client or agency concerned. The analysis of transportation cost, which is divided into variable costs by working hours The variable distance truck running. To propose in shipping all arrived quickly and cost ต่ำที่ ultimately from the findings. The main factors of variable according to working hours, pay the driver, were the main factors of 89.91 variable distance truck running. Is the fuel, were 77.45 from data analysis showed that the freight costs the company The distance, causes the transportation cost higher. It is, therefore, proposes the measures to reduce the cost of transportation system with the milk run by finding the shortest route, which found that The proposed approach reduces the distance of transportation. When the distance of drop shipping, affect the transport cost in each trip down along with it. By the 10.36 can reduce transportation costs.