Flavonoids serve a multiplicity of functions in eukariotic cells not only because of their location in
different cells and sub-cellular compartments, but also as a consequence of their chemical structures.
Stress-responsive flavonoids display a great potential to reduce various forms of reactive oxygen species, a common condition to which plants are faced with when experiencing different stresses of abiotic and biotic origin. Antioxidant flavonoids may contribute greatly to ROS-detoxification through chemical ROS quenching in plant cells, whereas in human cells, their functions as reducing agents appears of relatively minor significance. However, flavonoids may serve similar functions in plants and humans (in high nanomolar to low micromolar range) by tightly regulating the activities of different protein kinases, which, in turn, are responsible for mediating ROS-induced signaling cascades vital to cell growth and differentiation. These functional roles are effectively served by ROS-quenching flavonoids. The flavonoid-protein kinases relationships, which have been extensively investigated in humans, have not yet received attention in plants. Here we note that MAPKs are activated by oxidative stress signals and mediate responses of plants to vastly different stressors. Flavonoids have the potential to greatly affect MPAK signaling cascades in plants not only by directly binding to the active sites of the proteins, but also modulating their activation through ROS-scavenging activities.
Flavonoids serve a multiplicity of functions in eukariotic cells not only because of their location indifferent cells and sub-cellular compartments, but also as a consequence of their chemical structures.Stress-responsive flavonoids display a great potential to reduce various forms of reactive oxygen species, a common condition to which plants are faced with when experiencing different stresses of abiotic and biotic origin. Antioxidant flavonoids may contribute greatly to ROS-detoxification through chemical ROS quenching in plant cells, whereas in human cells, their functions as reducing agents appears of relatively minor significance. However, flavonoids may serve similar functions in plants and humans (in high nanomolar to low micromolar range) by tightly regulating the activities of different protein kinases, which, in turn, are responsible for mediating ROS-induced signaling cascades vital to cell growth and differentiation. These functional roles are effectively served by ROS-quenching flavonoids. The flavonoid-protein kinases relationships, which have been extensively investigated in humans, have not yet received attention in plants. Here we note that MAPKs are activated by oxidative stress signals and mediate responses of plants to vastly different stressors. Flavonoids have the potential to greatly affect MPAK signaling cascades in plants not only by directly binding to the active sites of the proteins, but also modulating their activation through ROS-scavenging activities.
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