This work emphasizes the important role played by the ankle pushoff function in knee joint mechanical loading during locomotion, andmay justify the inclusion of the TS MTU in prevention programs aiming to positively influence specific mechanical markers for knee osteoarthritis in the elderly. However,the study was unable to show that COMP is aminable to change in the elderly following a 14 week exercise intervention and,therefore, the physiological benefit of improved muscle function for knee cartilage requires further investigation.