tablet (GBT) on patients with vascular cognitive impairment of none dementia (VCIND). Methods:
A total of 80 patients with VCIND were divided into two groups randomly: Conventional treatment
group (control group) and combined treatment group. Conventional treatment group was given
conventional treatment with anti-platelet aggregation. In this group, 75 mg aspirin was given
three times a day for 3 months. While in combined treatment group, 19.2 mg GBT was given three
times a day for 3 months together with conventional treatment (anti-platelet aggregation drugs).
Montreal cognitive assessment (MoCA) and transcranial Doppler (TCD) were used to observe
changes of cognitive ability and cerebral blood flow in VCIND patients before and after treatment
in both groups. Then the clinical data were analyzed so as to compare the efficacy in two groups. Results: After 3 month-treatment in combined treatment group, the scores of executive ability,
attention, abstract, delayed memory, orientation in the MoCA were significantly increased
compared with those before treatment and those in control group after treatment. Besides, blood
flow velocity of anterior cerebral artery increased significantly than that before treatment and that
in control group after treatment. Conclusions: GBT tablet can improve the therapeutic efficacy
as well improve cognitive ability and cerebral blood flow supply of patients with VCIND
less AD dementia neuropathology than untreated hypertensive and normotensive subjects,7
while imaging studies showed preserved hippocampus in normotensive and treated hypertensive
subjects.8,9 However, clinical trials evaluating antihypertensive medications for dementia prevention
found no risk reduction,10–12 which could be explained by dementia being a secondary
outcome and therefore insufficiently powered. Additionally, the majority of these studies were
confounded by combined antihypertensive medication use11,13–16 to achieve acceptable blood
pressure. There are few studies with equivocal evidence regarding the role of hypertension
(HTN) and no randomized clinical trials evaluating the effects of antihypertensive medications
on progression of mild cognitive impairment (MCI) to dementia.17–19