Meanwhile, histologic analysis illustrated that CFCT alone or in
combination with CTX could induce tumor tissue necrosis of both models. In addition, CFCT at a dose of 50 or
100 mg/kg inhibited the lung metastasis of melanoma B16F10 in tumor-bearing C57BL/6 mice. The antimetastatic
effect was also observed when CFCT was used in combination with CTX. In comparison to any other groups, CFCT
at a dose of 100 mg/kg could effectively enhance the GSH-Px activities of various tissues in tumor-bearing C57BL/6
mice.