Rheumatoid arthritis is a chronic inflammatory autoimmune disease, which is characterized by a series of pathological processes of the joints, such as leukocyte infiltration, pannus formation and extensive destruction of the cartilage and bone. Cartilage degradation is mediated by enzymes such as matrix metalloproteinase and glycosidase. Pro-inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor (TNF), which are released during joint inflammation, stimulate production of these enzymes and promote cartilage degradation [1]. Though conventional treatment options for this condition have improved in terms of effectiveness, the use of non-steroidal anti-inflammatory drugs (NSAIDs) such as etoricoxib, disease modifying anti-rheumatic drugs (DMARDs) such as methotrexate,
sulphasalazine, leflunomide, hydroxychloroquine, and corticosteroids including prednisolone, methylprednisolone have all been associated with adverse effects [2]. Herbal medicines are being accepted and used increasingly by general populations in both eastern and western countries because of the ethnic acceptability and compatibility having fewer side effects [3]. This revival of herbal and other complementary therapies in the management of chronic diseases (RA