The basic principles in treating transfusion-associated bacterial sepsis include early clinical suspicion,
rigorous implementation of diagnostic procedures,
appropriate causal therapy,
inhibiting generalized inflammatory reactions predisposing to complications.
When a fast growing fever appears,
the transfusion should be discontinued,
the container with the accompanying drains secured,
and a blood sample taken from the patient so that microbiological tests can be done.
The blood sample for culturing should be taken from another vein than the one into which the blood component has been transfused.
Before microbiological tests findings are available, empiric therapy should be introduced.
Antibiotic therapy should include such broad spectrum
antibiotics as ß-lactams and aminoglycosides.
When bacterially contaminated red blood cell concentrate transfusion- associated sepsis is suspected, an antibiotic with anti-Pseudomonas activity should be introduced. Then targeted antibiotic therapy should be started. When a septic shock occurs, shock-controlling procedures should include monitoring hemodynamics, respiratory efficiency and kidney function. In fluid resuscitation, crystalloids and natural or artificial colloid solutions are used. The first transfusion consists of 500 – 1000 ml of crystalloids or 300 – 500 ml of colloids during 30 minutes, and is repeated depending on such parameters as blood pressure, diuresis, and possibly volume overload
The basic principles in treating transfusion-associated bacterial sepsis include early clinical suspicion, rigorous implementation of diagnostic procedures, appropriate causal therapy, inhibiting generalized inflammatory reactions predisposing to complications.When a fast growing fever appears, the transfusion should be discontinued, the container with the accompanying drains secured, and a blood sample taken from the patient so that microbiological tests can be done. The blood sample for culturing should be taken from another vein than the one into which the blood component has been transfused.Before microbiological tests findings are available, empiric therapy should be introduced. Antibiotic therapy should include such broad spectrum antibiotics as ß-lactams and aminoglycosides. When bacterially contaminated red blood cell concentrate transfusion- associated sepsis is suspected, an antibiotic with anti-Pseudomonas activity should be introduced. Then targeted antibiotic therapy should be started. When a septic shock occurs, shock-controlling procedures should include monitoring hemodynamics, respiratory efficiency and kidney function. In fluid resuscitation, crystalloids and natural or artificial colloid solutions are used. The first transfusion consists of 500 – 1000 ml of crystalloids or 300 – 500 ml of colloids during 30 minutes, and is repeated depending on such parameters as blood pressure, diuresis, and possibly volume overload
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