Epidemiological and experimental studies in cells, animal models of disease, and human
intervention trials demonstrate that fruit and vegetable polyphenolic compounds have
the potential to enhance wellness and even prevent, mitigate, and treat many illnesses
Oxidative stress
ROS/RNS
MAP kinase
ROS/RNS
ROS/RNS
Polyphenolics
Antioxidant activity Inflammation
(a)
GSH
Nrf2
GSSG
Kinases
NFk-b
Pro-inflammatory genes
(TNF-a, IL-1, IL-8, iNOS)
(b)
Antioxidant genes
(GSH, SOD, Hem oxygenase)
(c)
Polyphenolics
Figure 23.2The proposed mechanisms of action of fruit and vegetable polyphenolic compounds.
334 R.D. Hurst and S.M. Hurst
and disease conditions
and disease conditions.