All adenovirus infections appear to be followed by a latent carrier status and shedding of the virus;howver,this is poorly characterized for EAdV1.studies in the Pribright,United Kingdom (UK),pony herd indicated that EAdV1 infections were often subclinical,and that virus may persist in the nasopharyngeal mucus for up to 68 days after primary infection.Equine adenovirus type I was isolated from a foal,without clinical signs at time of isolation,at 3 day of age.It seems that foals may acquire infection from their dams or orther horses in their cohort during the suckling period,even in the presence of detectable levels of matermal antibody.Thus,if there is persisten or repeated EAdV infection,the passive immunity of the faoal would be converted to an active immunity,probanly without significant clinical disease.Disease may develop if primary infection occurred after maternal antibody had declined,or if the foal was unable to produce an active immune response.This overview of the early natural history of EAdV1 is supported by the natural of EAdV1 in Arabian foals with SCID,in which the transmission pattern and consequences of infection are viewed in the absence of an active immune response.
All adenovirus infections appear to be followed by a latent carrier status and shedding of the virus;howver,this is poorly characterized for EAdV1.studies in the Pribright,United Kingdom (UK),pony herd indicated that EAdV1 infections were often subclinical,and that virus may persist in the nasopharyngeal mucus for up to 68 days after primary infection.Equine adenovirus type I was isolated from a foal,without clinical signs at time of isolation,at 3 day of age.It seems that foals may acquire infection from their dams or orther horses in their cohort during the suckling period,even in the presence of detectable levels of matermal antibody.Thus,if there is persisten or repeated EAdV infection,the passive immunity of the faoal would be converted to an active immunity,probanly without significant clinical disease.Disease may develop if primary infection occurred after maternal antibody had declined,or if the foal was unable to produce an active immune response.This overview of the early natural history of EAdV1 is supported by the natural of EAdV1 in Arabian foals with SCID,in which the transmission pattern and consequences of infection are viewed in the absence of an active immune response.
การแปล กรุณารอสักครู่..
