in relation to the biological assembly of ConM. IAA molecules were positioned in the central cavity. The structural IAAs were positioned in a face-to-face arrangement relative to the indole group. Stacking hydrophobic interactions between the IAA rings stabilized the tetrameric form of ConM (Fig. 4). The amino acids that stabilize the
hydrophobic pocket are Ser108, Ser110, Val129, Asn131, Thr194, and Thr196.