reported the
combined inhibitory effects of isoflavones and curcumin on
prostate-specific antigen (PSA). The authors observed that the
production of PSA was markedly decreased by combined
treatment of isoflavones and curcumin in the prostate cancer
cell line LNCaP. The expression of androgen receptor was also
suppressed by this treatment. In clinical trials, 85 participants
were randomized to take a supplement containing isoflavones
and curcumin or placebo daily in a double-blind study. The
results showed that PSA levels decreased in the patient group
with PSA
10 treated with the supplement containing isoflavone
and curcumin (P = 0.01) [16]. The author then starts to
investigate a randomized, double-blind, placebo-controlled,
preventative study is now underway to postoperatively examine
the effects of curcumin on PSA elevation in prostate cancer
patients using Theracurmin.