Associations between sESAM and cardiovascular outcomes in
our analysis were attenuated after adjustment for eGFR. To our
knowledge, our study is the first to explicitly recognize this. Rohatgi
et al. in the Dallas Heart Study cohort found a significant correlation
between sESAM and aortic wall thickness, coronary calcium and
aortic stiffness [7], all measures of atherosclerosis that are used as
surrogates for clinical outcomes. In their study, ESAM was strongly
correlated with cystatin C, but multivariable models were not
adjusted for cystatin C or other measures of GFR [7].