This manuscript describes the COPE-III study, a randomized controlled trial evaluating the effectiveness of an innovative self-management approach in patients with a combination of COPD and other morbidities. A previously used symptom based
self-treatment strategy for non-complex patients with
COPD has been adjusted for use in patients with COPD and common comorbidities. The effectiveness of these adjusted action plans will be evaluated in patients with COPD and comorbidities.