The E factor corresponding to the synthesis of BDF-T2 has been calculated by using the same criteria. The syntheses of
available benzoquinone 1 and pentafluorophenyl acetonitrile 2 have not been considered (see the Supporting Information for
the calculation). The access to BDF-T2 from compounds 1, 2, and 4 gives E = 204 without taking into account the wastes
produced for the synthesis of aldehyde 4.