Present study on TCE does not impart any genotoxicity on
peripheral blood lymphocytes either through CA or through CBMN
assay in control or solvent exposed lymphocytes. It was further
confirmed that the genetic polymorphism in GSTs are not affecting by
the in vitro treatment of TCE on peripheral blood lymphocytes. In
general, the genetic polymorphism potentially important for biomarker
response largely depends on the exposing agent, biological material
examined and ethnicity of the population under study. Individual
exposure level may also be variable factor, and a reliable estimate of
the exposure may be supportive to interpret genotype toxicant
exposure interaction.