This paper argues that the quadratic assignment procedure (QAP) is superior to OLS for testing hypothesis in both simple and multiple regression models based on dyadic data, such as found in network analysis. A model of autocorrelation is proposed that is consistent with the assumptions of dyadic data. Results of Monte Carlo simulations indicate that OLS analysis is statistically biased, with the degree of bias varying as a function of the amount of structural autocorrelation. On the other hand, the simulations demonstrate that QAP is relatively unbiased. The Sampson data are used to illustrate the QAP multiple regression procedure and a general method of testing whether the results are statistically biased.