Natural product remedies are popular and gaining wide acceptability among people in the prevention and cure of diseases. The general belief that the products of natural origin are safe and free from serious side effects which the synthetic drugs possess drives people towards using the natural medicines. However, many of the natural product formulations available in the market do not have sufficient scientific data on their safety and toxicological profile. This assumes particular importance since the natural products are more often used under self-medication without a medical supervision. Hence, proper scientific knowledge on the toxicity and safe administration level of the natural medicines is crucial.