Xerosis (Figure 3) is a complication frequently observed in ESRD patients in 50-85% of the cases, mainly in patients who have not started dialysis. 7 It is known that in most cases it disappears after renal transplantation. It is classicaly absent in acute renal failure and is not correlated with the level of plasma urea. Uremic xerosis is suggested as the main factor in the onset of pruritus. It is believed that xerosis should be considered a syndrome, according to topography and presence of clinical signs, such as itching and skin turgor. The pathophysiological mechanism of xerosis is unknown, but there is probably a relationship between the dysfunction of eccrine glands and depletion of volume attributed to the use of diuretics.